The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss.

The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss.

Undifferentiated embryonal sarcoma of the liver (UESL) is a rare and aggressive malignancy. Though the molecular underpinnings of this cancer have been largely unexplored, recurrent chromosomal breakpoints affecting a noncoding region on chr19q13, which includes the chromosome 19 microRNA cluster (C...

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Bibliographic Details
Main Authors: Bhuvana A Setty, Goodwin G Jinesh, Michael Arnold, Fredrik Pettersson, Chia-Ho Cheng, Ling Cen, Sean J Yoder, Jamie K Teer, Elsa R Flores, Damon R Reed, Andrew S Brohl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008642

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https://doi.org/10.1371/journal.pgen.1008642

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