Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis

Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis

Lysophosphatidylserine (lysoPS) is known to regulate immune cell functions. Phospholipase A1 member A (PLA1A) can generate this bioactive lipid through hydrolysis of sn-1 fatty acids on phosphatidylserine (PS). PLA1A has been associated with cancer metastasis, asthma, as well as acute coronary syndr...

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Bibliographic Details
Main Authors: Yang Zhao, Stephan Hasse, Myriam Vaillancourt, Chenqi Zhao, Lynn Davis, Eric Boilard, Paul Fortin, John Di Battista, Patrice E. Poubelle, Sylvain G. Bourgoin
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
phosphatidylserine-specific phospholipase A1
lyso-phospholipid
lysophosphatidic acid
lyso-phosphatidylserine
autotaxin
chemokines
Online Access:https://www.mdpi.com/1422-0067/22/23/12685

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https://www.mdpi.com/1422-0067/22/23/12685

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