Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody

Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody

Echovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to comprehensively understand the specificities and the immunological characteristic of this serotype. The solved...

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Bibliographic Details
Main Authors: Shuai Qi, Wangjun Fu, Jinyan Fan, Li Zhang, Binyang Zheng, Kang Wang, Xiangxi Wang, Ling Zhu, Xinjian Li, Yuxia Zhang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
echovirus 3
monoclonal antibody (MAb)
cryo-EM single particle analysis
structures
C-terminus of VP1
vaccine
Online Access:https://www.mdpi.com/1999-4915/14/11/2322

Internet

https://www.mdpi.com/1999-4915/14/11/2322

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