Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP

Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP

The great interest in studying the structure of human purine nucleoside phosphorylase (<i>h</i>PNP) and the continued search for effective inhibitors is due to the importance of the enzyme as a target in the therapy of T-cell proliferative diseases. In addition, <i>h</i>PNP i...

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Bibliographic Details
Main Authors: Anastasia Khandazhinskaya, Ilja Fateev, Barbara Eletskaya, Anna Maslova, Irina Konstantinova, Katherine Seley-Radtke, Sergey Kochetkov, Elena Matyugina
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
aza/deazapurines
fleximer inhibitor
human purine nucleoside phosphorylase
Online Access:https://www.mdpi.com/1420-3049/28/3/928

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https://www.mdpi.com/1420-3049/28/3/928

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