Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4

Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4

Objectives: Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). Methods:...

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Bibliographic Details
Main Authors: Yoshihide Ichise, Jun Saegusa, Shino Tanaka-Natsui, Ikuko Naka, Shinya Hayashi, Ryosuke Kuroda, Akio Morinobu
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
fibroblast-like synoviocytes
rheumatoid arthritis
Soluble CD14
TLR-4
IL-6
TNF-α
Online Access:https://www.mdpi.com/2073-4409/9/7/1689

Internet

https://www.mdpi.com/2073-4409/9/7/1689

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