The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment

The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment

Abstract The 18kD translocator protein (TSPO) is used as a positron emission tomography (PET) target to quantify neuroinflammation in patients. In Alzheimer’s disease (AD), the cerebellum is the pseudo-reference region for comparison with the cerebral cortex due to the absence of AD pathology and lo...

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Bibliographic Details
Main Authors: Emma F. Garland, Oliver Dennett, Laurie C. Lau, David S. Chatelet, Michel Bottlaender, James A. R. Nicoll, Delphine Boche
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Neuroinflammation
Subjects:
TSPO
Alzheimer’s disease
Cerebellum
Pathology
Inflammation
Microglia
Online Access:https://doi.org/10.1186/s12974-023-02869-9

Internet

https://doi.org/10.1186/s12974-023-02869-9

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