In silico neoantigen screening and HLA multimer-based validation identify immunogenic neopeptide in multifocal lung adenocarcinoma

In silico neoantigen screening and HLA multimer-based validation identify immunogenic neopeptide in multifocal lung adenocarcinoma

BackgroundMutations commonly occur in cancer cells, arising neoantigen as potential targets for personalized immunotherapy of lung adenocarcinoma (LUAD). However, the substantial heterogeneity observed among individuals and distinct foci within the same patient presents significant challenges in for...

Full description

Bibliographic Details
Main Authors: Xin Wang, Lang Jiang, Juan Zhao, Mi Wu, Jin Xiong, Xiongwen Wu, Xiufang Weng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
neopeptide screening
multifocal lung adenocarcinoma
NANOGNB
immunogenicity neopeptide
artificial antigen-presenting cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1456209/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1456209/full

Similar Items