Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance

Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance

Aminopeptidase N (APN), also known as CD13 antigen or membrane alanyl aminopeptidase, belongs to the M1 family of the MA clan of zinc metallopeptidases. In cancer cells, the inhibition of aminopeptidases including APN causes the phenomenon termed the amino acid deprivation response (AADR), a stress...

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Bibliographic Details
Main Authors: Oldřich Farsa, Veronika Ballayová, Radka Žáčková, Peter Kollar, Tereza Kauerová, Peter Zubáč
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
aminopeptidase N
acetamidophenones
Schiff bases
semicarbazones
thiosemicarbazones
inhibition of proliferation
Online Access:https://www.mdpi.com/1422-0067/23/17/9813

Internet

https://www.mdpi.com/1422-0067/23/17/9813

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