Jak2 Inhibitor AG490 Improved Poststroke Central and Peripheral Inflammation and Metabolic Abnormalities in a Rat Model of Ischemic Stroke

Jak2 Inhibitor AG490 Improved Poststroke Central and Peripheral Inflammation and Metabolic Abnormalities in a Rat Model of Ischemic Stroke

Poststroke hyperglycemia and inflammation have been implicated in the pathogenesis of stroke. Janus Kinase 2 (Jak2), a catalytic signaling component for cytokine receptors such as Interleukin-6 (IL-6), has inflammatory and metabolic properties. This study aimed to investigate the roles of Jak2 in po...

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Bibliographic Details
Main Authors: Ya-Yu Wang, Shih-Yi Lin, Cheng-Yi Chang, Chih-Cheng Wu, Wen-Ying Chen, Su-Lan Liao, Yu-Fan Chen, Wen-Yi Wang, Chun-Jung Chen
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
hyperglycemia
IL-6
insulin resistance
neuroinflammation
stroke
Online Access:https://www.mdpi.com/2076-3921/10/12/1958

Internet

https://www.mdpi.com/2076-3921/10/12/1958

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