Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

The combination of elevated glucose and free-fatty acids (FFA), prevalent in diabetes, has been suggested to be a major contributor to pancreatic β-cell death. This study examines the synergistic effects of glucose and FFA on β-cell apoptosis and the molecular mechanisms involved. Mouse insulinoma c...

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Bibliographic Details
Main Authors: Katsuya Tanabe, Yang Liu, Syed D Hasan, Sara C Martinez, Corentin Cras-Méneur, Cris M Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J Rhodes, Erik Zmuda, Tsonwin Hai, Nada A Abumrad, M Alan Permutt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3082528?pdf=render

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http://europepmc.org/articles/PMC3082528?pdf=render

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