In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1 (PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used A...

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Bibliographic Details
Main Authors: Meng Yuan, Yao Tang, Tianwen Huang, Lining Ke, En Huang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Neural Regeneration Research
Subjects:
astrocyte; in situ direct reprogramming; ischemic stroke; mir-30 based shrna; neuron; polypyrimidine tract-binding protein 1; transdifferentiation
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=10;spage=2240;epage=2248;aulast=

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=10;spage=2240;epage=2248;aulast=

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