Ubiquitin‐specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma

Ubiquitin‐specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma

Abstract Ubiquitin‐specific protease 22 (USP22) has been identified as a potential marker for cancer stem cells in hepatocellular carcinoma (HCC). It can promote HCC stemness, which is considered a driver of tumorigenesis. Here, we sought to determine the role of USP22 in tumorigenesis, elucidate it...

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Bibliographic Details
Main Authors: Qianwei Ye, Wei Zhou, Shengjun Xu, Qingyang Que, Qifan Zhan, Lincheng Zhang, Shusen Zheng, Sunbin Ling, Xiao Xu
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:MedComm
Subjects:
autophagy
FK506‐binding protein 12 (FKBP12)
hepatocellular carcinoma (HCC)
mammalian target of rapamycin complex 1 (mTORC1)
tumorigenesis
ubiquitin‐specific protease 22 (USP22)
Online Access:https://doi.org/10.1002/mco2.439

Internet

https://doi.org/10.1002/mco2.439

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