Myocyte Enhancer Factor 2A Contributes to the TGF-β1-Mediated Cholangiocyte Epithelial to Mesenchymal Transition and Senescence in Cholestatic Liver Fibrosis

Myocyte Enhancer Factor 2A Contributes to the TGF-β1-Mediated Cholangiocyte Epithelial to Mesenchymal Transition and Senescence in Cholestatic Liver Fibrosis

Background: Cholangiocytes are primary targets in chronic cholestatic liver diseases. Myocyte enhancer factor 2A (MEF2A) is a transcription factor with a crucial role in some fibrogenic diseases. However, whether it contributes to cholestatic liver fibrosis is still obscure. Methods: A bile duct–lig...

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Bibliographic Details
Main Authors: Guangxi Zhou, Fei Hou, Heng He, Yuan Xue, Yibo Wang, Xueying Chen, Fengqin Zhu
Format: Article
Language:English
Published: IMR Press 2022-12-01
Series:Frontiers in Bioscience-Landmark
Subjects:
mef2a
emt
senescence
fibrosis
cholangiocytes
Online Access:https://www.imrpress.com/journal/FBL/27/12/10.31083/j.fbl2712324

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https://www.imrpress.com/journal/FBL/27/12/10.31083/j.fbl2712324

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