Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis

Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis

Agents that enhance production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) ameliorate the progression of renal fibrosis. However, the molecular mechanism of this process is not fully understood. We hypothesize that the antifibrotic effects of cGMP and cGMP‐dependent kinase I (cGKI...

Full description

Bibliographic Details
Main Authors: Elisabeth Schinner, Veronika Wetzl, Andrea Schramm, Frieder Kees, Peter Sandner, Johannes‐Peter Stasch, Franz Hofmann, Jens Schlossmann
Format: Article
Language:English
Published: Wiley 2017-04-01
Series:FEBS Open Bio
Subjects:
cGMP‐dependent protein kinase I
cyclic guanosine monophosphate
renal fibrosis
soluble guanylate cyclase stimulation
Online Access:https://doi.org/10.1002/2211-5463.12202

Internet

https://doi.org/10.1002/2211-5463.12202

Similar Items