Design and Synthesis of E-Selectin Antagonists

Design and Synthesis of E-Selectin Antagonists

Selectin-mediated recruitment of leukocytes plays a crucial role in a number of diseases and pathological situations, for example in inflammation, reperfusion injury, rheumatoid arthritis and respiratory diseases. Substantial research efforts are directed toward development of carbohydrate-...

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Bibliographic Details
Main Authors: Beat Ernst, Thomas Peters, Reinhold Oehrlein, Keith E. Norman, John L. Magnani, Wolfgang Jahnke, Beatrice Wagner, Christian Müller, Sébastien Marti, Zorica Dragic, Hartmuth C. Kolb
Format: Article
Language:deu
Published: Swiss Chemical Society 2001-04-01
Series:CHIMIA
Subjects:
Bioactive conformation
Chemical and chemo-enzymatic synthesis of glycomimetics
Molecular modeling
Preorganization
Selectin antagonists
Sialyl lewis x
Online Access:https://www.chimia.ch/chimia/article/view/3404

Internet

https://www.chimia.ch/chimia/article/view/3404

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