Siplizumab Induces NK Cell Fratricide Through Antibody-Dependent Cell-Mediated Cytotoxicity

Siplizumab Induces NK Cell Fratricide Through Antibody-Dependent Cell-Mediated Cytotoxicity

The glycoprotein CD2 is expressed on T and NK cells and contributes to cell-cell conjugation, agonistic signaling and actin cytoskeleton rearrangement. CD2 has previously been shown to have an important function in natural NK cell cytotoxicity but to be expendable in antibody-mediated cytotoxicity....

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Bibliographic Details
Main Authors: Christian Binder, Felix Sellberg, Filip Cvetkovski, Stefan Berg, Erik Berglund, David Berglund
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
NK cell
CD2
siplizumab
spontaneous cytotoxicity
antibody-dependent cell-mediated cytotoxicity
NK alloreactivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.599526/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.599526/full

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