The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling

The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling

Abstract Background Systemic sclerosis (SSc) is a collagen disease that exhibits intractable fibrosis and vascular injury of the skin and internal organs. Transforming growth factor-β (TGF-β)/Smad signaling plays a central role in extracellular matrix (ECM) production by α-SMA-positive myofibroblast...

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Bibliographic Details
Main Authors: Akira Utsunomiya, Takenao Chino, Hiroshi Kasamatsu, Takumi Hasegawa, Natsuko Utsunomiya, Vu Huy Luong, Takashi Matsushita, Yoko Sasaki, Dai Ogura, Shin-ichiro Niwa, Noritaka Oyama, Minoru Hasegawa
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Fibrosis
Vascular injury
Therapy
Mouse model
TGF-β
Online Access:https://doi.org/10.1186/s13075-022-02773-2

Internet

https://doi.org/10.1186/s13075-022-02773-2

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