CD38 regulates ovarian function and fecundity via NAD+ metabolism

CD38 regulates ovarian function and fecundity via NAD+ metabolism

Summary: Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that CD38, an NAD+ consuming enzyme, is expressed...

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Bibliographic Details
Main Authors: Rosalba Perrone, Prasanna Vadhana Ashok Kumaar, Lauren Haky, Cosmo Hahn, Rebeccah Riley, Julia Balough, Giuliana Zaza, Bikem Soygur, Kaitlyn Hung, Leandro Prado, Herbert G. Kasler, Ritesh Tiwari, Hiroyuki Matsui, Genesis Vega Hormazabal, Indra Heckenbach, Morten Scheibye-Knudsen, Francesca E. Duncan, Eric Verdin
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Biological sciences
Biochemistry
Physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223020266

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http://www.sciencedirect.com/science/article/pii/S2589004223020266

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