The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C

The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C

Abstract Background Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity against GBM in preclinical studies. The good safety profile of SpyADI ren...

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Bibliographic Details
Main Authors: Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen, Claudia Maletzki
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cancer Cell International
Subjects:
Arginine auxotrophy
Senescence
Long-term treatment
3D culture
Radiation
Stemness
Online Access:https://doi.org/10.1186/s12935-023-02873-2

Internet

https://doi.org/10.1186/s12935-023-02873-2

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