The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/9/1043 |
| _version_ | 1797554658066038784 |
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| author | Ivana Bjedov Charalampos Rallis |
| author_facet | Ivana Bjedov Charalampos Rallis |
| author_sort | Ivana Bjedov |
| collection | DOAJ |
| description | Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling pathway is implicated in multiple age-related diseases such as cancer, neurodegeneration, and auto-immunity. In this review, we briefly summarise some of the workings of mTOR in lifespan and ageing through the processes of transcription, translation, autophagy, and metabolism. A good understanding of the pathway’s outputs and connectivity is paramount towards our ability for genetic and pharmacological interventions for healthy ageing and amelioration of age-related disease. |
| first_indexed | 2024-03-10T16:35:09Z |
| format | Article |
| id | doaj.art-b68e2e3c9c9049a4b50a11b372ae118e |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T16:35:09Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-b68e2e3c9c9049a4b50a11b372ae118e2023-11-20T12:31:21ZengMDPI AGGenes2073-44252020-09-01119104310.3390/genes11091043The Target of Rapamycin Signalling Pathway in Ageing and Lifespan RegulationIvana Bjedov0Charalampos Rallis1UCL Cancer Institute, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6DD, UKSchool of Life Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UKAgeing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy sensing diverse inputs such as amino acids, oxygen, hormones, and stress and regulates lifespan by tuning cellular functions such as gene expression, ribosome biogenesis, proteostasis, and mitochondrial metabolism. Deregulation of the mTOR signalling pathway is implicated in multiple age-related diseases such as cancer, neurodegeneration, and auto-immunity. In this review, we briefly summarise some of the workings of mTOR in lifespan and ageing through the processes of transcription, translation, autophagy, and metabolism. A good understanding of the pathway’s outputs and connectivity is paramount towards our ability for genetic and pharmacological interventions for healthy ageing and amelioration of age-related disease.https://www.mdpi.com/2073-4425/11/9/1043ageing<i>Drosophila</i>yeastnutrient-responseautophagytranslation |
| spellingShingle | Ivana Bjedov Charalampos Rallis The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation Genes ageing <i>Drosophila</i> yeast nutrient-response autophagy translation |
| title | The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation |
| title_full | The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation |
| title_fullStr | The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation |
| title_full_unstemmed | The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation |
| title_short | The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation |
| title_sort | target of rapamycin signalling pathway in ageing and lifespan regulation |
| topic | ageing <i>Drosophila</i> yeast nutrient-response autophagy translation |
| url | https://www.mdpi.com/2073-4425/11/9/1043 |
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