The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
Ageing is a complex trait controlled by genes and the environment. The highly conserved mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan in all eukaryotes and is thought to be mediating some of the effects of dietary restriction. mTOR is a rheostat of energy...
Main Authors: | Ivana Bjedov, Charalampos Rallis |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-09-01
|
Series: | Genes |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4425/11/9/1043 |
Similar Items
-
Nutrient-Response Pathways in Healthspan and Lifespan Regulation
by: Aleksandra Dabrowska, et al.
Published: (2022-05-01) -
Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
by: Zheng Hu, et al.
Published: (2018-08-01) -
Potent New Targets for Autophagy Enhancement to Delay Neuronal Ageing
by: Janka Szinyákovics, et al.
Published: (2023-06-01) -
The Case for the Target of Rapamycin Pathway as a Candidate Circadian Oscillator
by: Patricia Lakin-Thomas
Published: (2023-08-01) -
Exercising <i>D. melanogaster</i> Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex
by: Brad Ebanks, et al.
Published: (2021-10-01)