Amphiphilic Poly(<i>N</i>-vinylpyrrolidone) Nanoparticles Conjugated with DR5-Specific Antitumor Cytokine DR5-B for Targeted Delivery to Cancer Cells

Amphiphilic Poly(<i>N</i>-vinylpyrrolidone) Nanoparticles Conjugated with DR5-Specific Antitumor Cytokine DR5-B for Targeted Delivery to Cancer Cells

Nanoparticles based on the biocompatible amphiphilic poly(<i>N</i>-vinylpyrrolidone) (Amph-PVP) derivatives are promising for drug delivery. Amph-PVPs self-aggregate in aqueous solutions with the formation of micellar nanoscaled structures. Amph-PVP nanoparticles are able to immobilize t...

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Bibliographic Details
Main Authors: Anne Yagolovich, Andrey Kuskov, Pavel Kulikov, Leily Kurbanova, Dmitry Bagrov, Artem Artykov, Marine Gasparian, Svetlana Sizova, Vladimir Oleinikov, Anastasia Gileva, Mikhail Kirpichnikov, Dmitry Dolgikh, Elena Markvicheva
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
poly(<i>N</i>-vinylpyrrolidone)
self-assembly
nanoparticles
targeted drug delivery system
DR5 receptor
TRAIL variant DR5-B
Online Access:https://www.mdpi.com/1999-4923/13/9/1413

Internet

https://www.mdpi.com/1999-4923/13/9/1413

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