Combined therapy with methotrexate nanoconjugate and dendritic cells with downregulated IL-10R expression modulates the tumor microenvironment and enhances the systemic anti-tumor immune response in MC38 murine colon carcinoma

Combined therapy with methotrexate nanoconjugate and dendritic cells with downregulated IL-10R expression modulates the tumor microenvironment and enhances the systemic anti-tumor immune response in MC38 murine colon carcinoma

BackgroundUnderstanding the negative impact of the tumor microenvironment on the creation of an effective immune response has contributed to the development of new therapeutic anti-cancer strategies. One such solution is combined therapy consisting of chemotherapeutic administration followed by dend...

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Bibliographic Details
Main Authors: Agnieszka Szczygieł, Katarzyna Węgierek-Ciura, Anna Wróblewska, Jagoda Mierzejewska, Joanna Rossowska, Bożena Szermer-Olearnik, Marta Świtalska, Natalia Anger-Góra, Tomasz M. Goszczyński, Elżbieta Pajtasz-Piasecka
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
dendritic cells
lentiviral (LV) vector
nanoconjugate
methotrexate
immunomodulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1155377/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1155377/full

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