Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling

Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling

Osteoarthritis (OA) is a common articular disease manifested by the destruction of cartilage and compromised chondrogenesis in the aging population, with chronic inflammation of synovium, which drives OA progression. Importantly, the activated synovial fibroblast (AF) within the synovium facilitates...

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Bibliographic Details
Main Authors: Pei-Wei Weng, Vijesh Kumar Yadav, Narpati Wesa Pikatan, Iat-Hang Fong, I-Hsin Lin, Chi-Tai Yeh, Wei-Hwa Lee
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis (OA)
NFκB inflammatory circuit
miR-21/GDF-5/SOX5 signaling
NFκB inhibitor
therapeutics
Online Access:https://www.mdpi.com/1422-0067/22/20/11082

Internet

https://www.mdpi.com/1422-0067/22/20/11082

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