Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury

Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury

Background and purpose: Xin-Ji-Er-Kang (XJEK) is traditional Chinese formula presented excellent protective effects on several heart diseases, but the potential components and targets are still unclear. The aim of this study is to elucidate the effective components of XJEK and reveal its potential m...

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Bibliographic Details
Main Authors: Kai Zhou, Hua Chen, Xiao-yu Wang, Yan-mei Xu, Yu-feng Liao, Yuan-yuan Qin, Xue-wan Ge, Ting-ting Zhang, Zhong-lin Fang, Bei-bei Fu, Qing-Zhong Xiao, Feng-qin Zhu, Si-rui Chen, Xue-sheng Liu, Qi-chao Luo, Shan Gao
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
XJEK
Myocardial ischemia reperfusion
JAK2
Pharmacokinetics
Bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222011817

Internet

http://www.sciencedirect.com/science/article/pii/S0753332222011817

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