Pre-existing anti-drug antibodies in Fabry disease show less affinity for pegunigalsidase alfa

Pre-existing anti-drug antibodies in Fabry disease show less affinity for pegunigalsidase alfa

We analyzed the cross-reactivity of anti-drug antibodies (ADAs) against agalsidase-alfa and -beta from 49 patients with Fabry disease (FD) against the novel PEGylated enzyme pegunigalsidase-alfa (PRX-102). The affinity of purified anti-AGAL antibodies from pooled patient sera was significantly lower...

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Bibliographic Details
Main Authors: Malte Lenders, Solvey Pollmann, Melina Terlinden, Eva Brand
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
anti-drug antibodies
affinity
enzyme replacement therapy
Fabry disease
pegunigalsidase alfa
enzyme uptake
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001012

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http://www.sciencedirect.com/science/article/pii/S2329050122001012

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