A Brominated Furanone Inhibits <i>Pseudomonas aeruginosa</i> Quorum Sensing and Type III Secretion, Attenuating Its Virulence in a Murine Cutaneous Abscess Model

A Brominated Furanone Inhibits <i>Pseudomonas aeruginosa</i> Quorum Sensing and Type III Secretion, Attenuating Its Virulence in a Murine Cutaneous Abscess Model

Quorum sensing (QS) and type III secretion systems (T3SSs) are among the most attractive anti-virulence targets for combating multidrug-resistant pathogenic bacteria. Some halogenated furanones reduce QS-associated virulence, but their role in T3SS inhibition remains unclear. This study aimed to ass...

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Bibliographic Details
Main Authors: Naybi Muñoz-Cázares, Israel Castillo-Juárez, Rodolfo García-Contreras, Víctor Alberto Castro-Torres, Miguel Díaz-Guerrero, José S. Rodríguez-Zavala, Héctor Quezada, Bertha González-Pedrajo, Mariano Martínez-Vázquez
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
<i>Pseudomonas aeruginosa</i>
type III secretion system
abscess mouse model
brominated furanone
Online Access:https://www.mdpi.com/2227-9059/10/8/1847

Internet

https://www.mdpi.com/2227-9059/10/8/1847

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