A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes

A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes

Multifunctional human collagen lysyl hydroxylase (LH/PLOD) enzymes catalyze post-translational hydroxylation and subsequent glycosylation of collagens, enabling their maturation and supramolecular organization in the extracellular matrix (ECM). Recently, the overexpression of LH/PLODs in the tumor m...

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Bibliographic Details
Main Authors: Luigi Scietti, Elisabetta Moroni, Daiana Mattoteia, Marco Fumagalli, Matteo De Marco, Lisa Negro, Antonella Chiapparino, Stefano A. Serapian, Francesca De Giorgi, Silvia Faravelli, Giorgio Colombo, Federico Forneris
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
collagen
lysyl hydroxylase (LH)
Fe2+/2-oxoglutarate-dependent dioxygenases
structure-based drug design
molecular dynamics simulations
cancer metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.876352/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.876352/full

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