CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

Abstract Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs. Because the insulator protein CTCF is enriched at LAD borders, it was postulated that CTCF bi...

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Bibliographic Details
Main Authors: Tom van Schaik, Ning Qing Liu, Stefano G. Manzo, Daan Peric-Hupkes, Elzo de Wit, Bas van Steensel
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Biology
Subjects:
Nuclear lamina
Lamina-associated domains
pA-DamID
CTCF
Cohesin
Acute protein depletion
Online Access:https://doi.org/10.1186/s13059-022-02754-3

Internet

https://doi.org/10.1186/s13059-022-02754-3

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