Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier

Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier

Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) is critical for the pathogenesis of Escherichia coli (E. coli) K1 meningitis, a severe central nervous system infection of the neonates. However, little is known about how E. coli K1 manipulates α7 nAChR signaling. Here, through employing immortali...

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Bibliographic Details
Main Authors: Xiaolong He, Lei Wang, Liqun Liu, Jie Gao, Beiguo Long, Feng Chi, Tongtong Hu, Yu Wan, Zelong Gong, Li Li, Peilin Zhen, Tiesong Zhang, Hong Cao, Sheng-He Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
SLURP1
E. coli K1 meningitis
blood-brain barrier
inflammation
α7 nAChR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.745854/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.745854/full

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