Insight into the outer membrane asymmetry of P. aeruginosa and the role of MlaA in modulating the lipidic composition, mechanical, biophysical, and functional membrane properties of the cell envelope

Insight into the outer membrane asymmetry of P. aeruginosa and the role of MlaA in modulating the lipidic composition, mechanical, biophysical, and functional membrane properties of the cell envelope

ABSTRACT In Gram-negative bacteria, the outer membrane (OM) is asymmetric, with lipopolysaccharides (LPS) in the outer leaflet and glycerophospholipids (GPLs) in the inner leaflet. The asymmetry is maintained by the Mla system (MlaA-MlaBCDEF), which contributes to lipid homeostasis by removing mislo...

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Bibliographic Details
Main Authors: M. Kaur, N. Mozaheb, T. O. Paiva, M.-F. Herent, F. Goormaghtigh, A. Paquot, R. Terrasi, E. Mignolet, J.-L. Décout, J. H. Lorent, Y. Larondelle, G. G. Muccioli, J. Quetin-Leclercq, Y. F. Dufrêne, M.-P. Mingeot-Leclercq
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:Microbiology Spectrum
Subjects:
P. aeruginosa
outer membrane
membrane biophysics
lipids
cell envelope
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01484-24

Internet

https://journals.asm.org/doi/10.1128/spectrum.01484-24

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