Simplifying glycan monitoring of complex antigens such as the SARS-CoV-2 spike to accelerate vaccine development

Simplifying glycan monitoring of complex antigens such as the SARS-CoV-2 spike to accelerate vaccine development

Abstract Glycosylation is a key quality attribute that must be closely monitored for protein therapeutics. Established assays such as HILIC-Fld of released glycans and LC-MS of glycopeptides work well for glycoproteins with a few glycosylation sites but are less amenable for those with multiple glyc...

Full description

Bibliographic Details
Main Authors: Janelle Sauvageau, Izel Koyuturk, Frank St. Michael, Denis Brochu, Marie-France Goneau, Ian Schoenhofen, Sylvie Perret, Alexandra Star, Anna Robotham, Arsalan Haqqani, John Kelly, Michel Gilbert, Yves Durocher
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-023-00988-1

Internet

https://doi.org/10.1038/s42004-023-00988-1

Similar Items