Endogenous Extracellular Matrix Regulates the Response of Osteosarcoma 3D Spheroids to Doxorubicin

Endogenous Extracellular Matrix Regulates the Response of Osteosarcoma 3D Spheroids to Doxorubicin

The extracellular matrix (ECM) modulates cell behavior, shape, and viability as well as mechanical properties. In recent years, ECM disregulation and aberrant remodeling has gained considerable attention in cancer targeting and prevention since it may stimulate tumorigenesis and metastasis. Here, we...

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Bibliographic Details
Main Authors: Margherita Cortini, Francesca Macchi, Francesca Reggiani, Emanuele Vitale, Maria Veronica Lipreri, Francesca Perut, Alessia Ciarrocchi, Nicola Baldini, Sofia Avnet
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
osteosarcoma
3D models
extracellular matrix
collagen
spheroids
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/15/4/1221

Internet

https://www.mdpi.com/2072-6694/15/4/1221

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