Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1)

Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1)

N-methyl-D-aspartate (NMDA) receptors play a critical role in activity-dependent dendritic arborization, spinogenesis, and synapse formation by stimulating calcium-dependent signaling pathways. Previously, we have shown that brevetoxin 2 (PbTx-2), a voltage-gated sodium channel (VGSC) activator, pro...

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Bibliographic Details
Main Authors: Suneet Mehrotra, Marsha L. Pierce, Shashank M. Dravid, Thomas F. Murray
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Marine Drugs
Subjects:
brevetoxin 2 (PbTx-2)
voltage-gated sodium channel (VGSC)
N-methyl-D-aspartate (NMDA) receptor 2b (GluN2B)
voltage-gated calcium channel (VGCC)
p21 protein (Cdc42/Rac1)-activated kinase 1 (PAK1)
L-type calcium channel
Online Access:https://www.mdpi.com/1660-3397/20/9/559

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https://www.mdpi.com/1660-3397/20/9/559

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