Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion

Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion

Selective kappa opioid receptor (KOR) agonists are promising antipruritic agents and analgesics. However, clinical development of KOR agonists has been limited by side effects, including psychotomimetic effects, dysphoria, and sedation, except for nalfurafine, and recently. CR845 (difelikefalin). Ac...

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Bibliographic Details
Main Authors: Chongguang Chen, Peng Huang, Kathryn Bland, Mengchu Li, Yan Zhang, Lee-Yuan Liu-Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
kappa opioid receptor
receptor phosphorylation
receptor internalization
conditioned place aversion
sedation
motor incoordination
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.835809/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.835809/full

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