A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic <i>Vibrio cholerae</i>

A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic <i>Vibrio cholerae</i>

<i>Vibrio cholerae</i> uses cholera toxin (CT) to cause cholera, a severe diarrheal disease in humans that can lead to death within hours of the onset of symptoms. The catalytic activity of CT in target epithelial cells increases cellular levels of 3′,5′-cyclic AMP (cAMP), leading to the...

Full description

Bibliographic Details
Main Authors: Fabian Rivera-Chávez, Bradley T. Meader, Sinan Akosman, Vuk Koprivica, John J. Mekalanos
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Toxins
Subjects:
cholera toxin
<i>Vibrio cholerae</i>
diarrheal syndromes
anti-infective drug therapy
Online Access:https://www.mdpi.com/2072-6651/14/3/225

Internet

https://www.mdpi.com/2072-6651/14/3/225

Similar Items