Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer

Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer

Abstract CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of immunotherapy against microsatellite stable (MSS) CRC is limited. Little is known about the most critical features of CR...

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Bibliographic Details
Main Authors: Daniel Morales Borràs, Sara Verbandt, Markus Ausserhofer, Gregor Sturm, Jinyeong Lim, Gil Arasa Verge, Isaure Vanmeerbeek, Raquel S. Laureano, Jannes Govaerts, Jenny Sprooten, Yourae Hong, Rebecca Wall, Gert De Hertogh, Xavier Sagaert, Gabriele Bislenghi, André D’Hoore, Albert Wolthuis, Francesca Finotello, Woong-Yang Park, Stefan Naulaerts, Sabine Tejpar, Abhishek D. Garg
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00605-4

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https://doi.org/10.1038/s41421-023-00605-4

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