Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase A2 Activity at Cytoplasmic pH

Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase A2 Activity at Cytoplasmic pH

The expression of the phospholipase A2 activity (aiPLA2) of peroxiredoxin 6 (Prdx6) in the cell cytoplasm is physiologically relevant for the repair of peroxidized cell membranes, but aiPLA2 assay in vitro indicates that, unlike assay at pH 4, activity at cytosolic pH is essentially absent with non-...

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Bibliographic Details
Main Authors: Suiping Zhou, Chandra Dodia, Sheldon I. Feinstein, Sandra Harper, Henry J. Forman, David W. Speicher, Aron B. Fisher
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Antioxidants
Subjects:
substrate binding
sulfinic acid
Prdx6 structure
mass spectroscopic analysis
Online Access:http://www.mdpi.com/2076-3921/8/1/4

Internet

http://www.mdpi.com/2076-3921/8/1/4

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