NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells

NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells

Background The natural killer (NK) complex (NKC) harbors multiple genes such as KLRC1 (encoding NKG2A) and KLRK1 (encoding NKG2D) that are central to regulation of NK cell function. We aimed at determining to what extent NKC haplotypes impact on NK cell repertoire and function, and whether such gene...

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Bibliographic Details
Main Authors: Brwa Ali Hussein, Linnea Kristenson, Silvia Pesce, Anne Wöhr, Yarong Tian, Alexander Hallner, Mats Brune, Kristoffer Hellstrand, Ka-Wei Tang, Elin Bernson, Fredrik B Thorén
Format: Article
Language:English
Published: BMJ Publishing Group 2023-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/8/e007202.full

Internet

https://jitc.bmj.com/content/11/8/e007202.full

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