Differential mitochondrial toxicity screening and multi-parametric data analysis.

Differential mitochondrial toxicity screening and multi-parametric data analysis.

Early evaluation of new drug entities for their potential to cause mitochondrial dysfunction is becoming an important task for drug development. Multi-parametric high-content screening (mp-HCS) of mitochondrial toxicity holds promise as a lead in-vitro strategy for drug testing and safety evaluation...

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Main Authors: Maria V Tsiper, Jennifer Sturgis, Larisa V Avramova, Shilpa Parakh, Raymond Fatig, Ana Juan-García, Nianyu Li, Bartek Rajwa, Padma Narayanan, C W Qualls, J Paul Robinson, V Jo Davisson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3471932?pdf=render

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http://europepmc.org/articles/PMC3471932?pdf=render

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