Flat dose regimen of toripalimab based on model-informed drug development approach

Flat dose regimen of toripalimab based on model-informed drug development approach

Introduction: Flat dosing regimen has recently been approved for programmed death receptor-1 (PD-1) inhibitors including toripalimab, nivolumab and pembrolizumab. The objective of this study is to provide pharmacological evidence for a flat dosing regimen of toripalimab by assessing the efficacy and...

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Bibliographic Details
Main Authors: Lili Li, Jianye Qu, Ming Song, Qun Zhao, Yonghua Yang, Xi Tan, Yanyan Hu, Jing Li, Yunfei Lin, Hui Feng, Sheng Yao, Patricia Keegan, Meixia Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
flat dose
toripalimab
model-informed drug development approach
population pharmacokinetics
exposure-response analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1069818/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1069818/full

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