Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

<p>Abstract</p> <p>Background</p> <p>Microglia are considered a major target for modulating neuroinflammatory and neurodegenerative disease processes. Upon activation, microglia secrete inflammatory mediators that contribute to the resolution or to further enhancement o...

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Bibliographic Details
Main Authors: de Oliveira Antonio CP, Candelario-Jalil Eduardo, Langbein Julia, Wendeburg Lena, Bhatia Harsharan S, Schlachetzki Johannes CM, Biber Knut, Fiebich Bernd L
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Journal of Neuroinflammation
Subjects:
microglia
phosphatidylinositol 3-kinase
mammalian target of rapamycin
glycogen synthase kinase-3
Akt
prostaglandins
Online Access:http://www.jneuroinflammation.com/content/9/1/2

Internet

http://www.jneuroinflammation.com/content/9/1/2

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