Technical Study of Automated High-Throughput High-Sensitive Ceruloplasmin Assay on Dried Blood Spots—Reinstate the Potential Use for Newborn Screening of Wilson Disease

Technical Study of Automated High-Throughput High-Sensitive Ceruloplasmin Assay on Dried Blood Spots—Reinstate the Potential Use for Newborn Screening of Wilson Disease

In this study, we modified a fully automatic immunoassay on ceruloplasmin concentration on dried blood spots (DBS) to increase its analytical sensitivity in order to accurately differentiate newborns from true Wilson disease (WD) patients. Modifications to the assay parameters of the Roche/Hitachi C...

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Bibliographic Details
Main Authors: Chloe Miu Mak, Ching Tung Choi, Tsz Ki Wong, Hanson Heearn Chin, Hillman Kai Yin Lai, Koon Yu Yuet
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Neonatal Screening
Subjects:
newborn screening
Wilson disease
ceruloplasmin
high-sensitive assay
dried blood spot
Online Access:https://www.mdpi.com/2409-515X/8/4/64

Internet

https://www.mdpi.com/2409-515X/8/4/64

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