Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition

The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs). Moreover, in humans, the gut microbiota converts the primary BAs,...

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Bibliographic Details
Main Authors: Akira Honda, Teruo Miyazaki, Junichi Iwamoto, Takeshi Hirayama, Yukio Morishita, Tadakuni Monma, Hajime Ueda, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tadashi Ikegami
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Lipid Research
Subjects:
CRISPR-Cas9
cytochrome P450
CYP2A12
CYP2C70
cholesterol 7α-hydroxylase
7α-hydroxy-4-cholesten-3-one 12α-hydroxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752030016X

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http://www.sciencedirect.com/science/article/pii/S002222752030016X

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