Aerobic Cytotoxicity of Aromatic <i>N-</i>Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1)

Aerobic Cytotoxicity of Aromatic <i>N-</i>Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1)

Derivatives of tirapazamine and other heteroaromatic <i>N-</i>oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities, which are typically attributed to bioreductive activation and free radical generation. In this work, we aimed to clarify the role of NAD(P)H:quin...

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Bibliographic Details
Main Authors: Aušra Nemeikaitė-Čėnienė, Jonas Šarlauskas, Lina Misevičienė, Audronė Marozienė, Violeta Jonušienė, Mindaugas Lesanavičius, Narimantas Čėnas
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
tirapazamine
reductive activation
NAD(P)H:quinone oxidoreductase
oxidative stress
cytotoxicity
Online Access:https://www.mdpi.com/1422-0067/21/22/8754

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https://www.mdpi.com/1422-0067/21/22/8754

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