Assisted protein folding at low temperature: evolutionary adaptation of the Antarctic fish chaperonin CCT and its client proteins

Assisted protein folding at low temperature: evolutionary adaptation of the Antarctic fish chaperonin CCT and its client proteins

Eukaryotic ectotherms of the Southern Ocean face energetic challenges to protein folding assisted by the cytosolic chaperonin CCT. We hypothesize that CCT and its client proteins (CPs) have co-evolved molecular adaptations that facilitate CCT–CP interaction and the ATP-driven folding cycle at low te...

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Bibliographic Details
Main Authors: Jorge Cuellar, Hugo Yébenes, Sandra K. Parker, Gerardo Carranza, Marina Serna, José María Valpuesta, Juan Carlos Zabala, H. William Detrich
Format: Article
Language:English
Published: The Company of Biologists 2014-03-01
Series:Biology Open
Subjects:
CCT
TriC
Chaperone
Chaperonin
Protein folding
Actin
Tubulin
Thermal adaptation
Evolution
Online Access:http://bio.biologists.org/content/3/4/261

Internet

http://bio.biologists.org/content/3/4/261

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