A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice.

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice.

Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically by the preferential vulnerability of the dopaminergi...

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Main Authors: Alexander Kurz, Kay L Double, Isabel Lastres-Becker, Alessandro Tozzi, Michela Tantucci, Vanessa Bockhart, Michael Bonin, Moisés García-Arencibia, Silke Nuber, Falk Schlaudraff, Birgit Liss, Javier Fernández-Ruiz, Manfred Gerlach, Ullrich Wüllner, Hartmut Lüddens, Paolo Calabresi, Georg Auburger, Suzana Gispert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2898885?pdf=render

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http://europepmc.org/articles/PMC2898885?pdf=render

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