Transcriptomic Evidence of the Immune Response Activation in Individuals With Limb Girdle Muscular Dystrophy Dominant 2 (LGMDD2) Contributes to Resistance to HIV-1 Infection

Transcriptomic Evidence of the Immune Response Activation in Individuals With Limb Girdle Muscular Dystrophy Dominant 2 (LGMDD2) Contributes to Resistance to HIV-1 Infection

LGMDD2 is a rare form of muscular dystrophy characterized by one of the three heterozygous deletions described within the TNPO3 gene that result in the addition of a 15-amino acid tail in the C-terminus.TNPO3 is involved in the nuclear import of splicing factors and acts as a host cofactor for HIV-1...

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Bibliographic Details
Main Authors: Francisco Diez-Fuertes, María Rosa López-Huertas, Javier García-Pérez, Esther Calonge, Mercedes Bermejo, Elena Mateos, Pilar Martí, Nuria Muelas, Juan Jesús Vílchez, Mayte Coiras, José Alcamí, Sara Rodríguez-Mora
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HIV-1
LGMDD2
transcriptome
chemokines
inflammation pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.839813/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.839813/full

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