Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration

Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration

Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphory...

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Bibliographic Details
Main Authors: Hussam E Salhi, Nathan C Hassel, Jalal K Siddiqui, Elizabeth A Brundage, Mark T Ziolo, Paul M L Janssen, Jonathan P Davis, Brandon J Biesiadecki
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Physiology
Subjects:
Phosphorylation
Functional integration
Myofilament
calcium sensitivity of cardiomyocytes
Cardiac troponin I
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00567/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00567/full

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