Passage number affects differentiation of sensory neurons from human induced pluripotent stem cells

Abstract Induced pluripotent stem cells (iPSCs) are a valuable resource for neurological disease-modeling and drug discovery due to their ability to differentiate into neurons reflecting the genetics of the patient from which they are derived. iPSC-derived cultures, however, are highly variable due...

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Bibliographic Details
Main Authors: Erica L. Cantor, Fei Shen, Guanglong Jiang, Zhiyong Tan, Geneva M. Cunningham, Xi Wu, Santosh Philips, Bryan P. Schneider
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19018-6